MasSpec probe: rapid diagnosis of cancer tissue in 20 seconds

Imagine if you could detect cancer tissue in a matter of seconds, it would be very helpful. The Livia Eberlin research team at the University of Texas announced that they have developed a similar cancer detection technology.

The research team developed a MasSpec probe that can detect cancer tissue in real time during surgery, and the device debuted at this week's SXSW festival. Research team's assistant researcher Marta Sans said: "The MasSpec pen is a handheld device that can be used to diagnose cancer tissue within 20 seconds of the mass spectrometer."

This type of probe can be placed directly on the tissue to make a diagnosis through contact. The doctor can manipulate the probe through the foot switch, which will release water droplets and extract molecules from the tissue through water droplets. These droplets will then be analyzed by molecular mass spectrometry.

MasSpec probe: rapid diagnosis of cancer tissue in 20 seconds

“So we can create a molecular fingerprint based on the molecules collected by the probe and determine if it is a cancer tissue,” Sans said. For doctors, the technology is groundbreaking. It is sometimes difficult to distinguish cancer tissue from normal tissue during surgery, and waiting for a pathologist's analysis usually takes a long time.

Dr. Leonard Lichtenfeld, a medical officer at the American Cancer Society, said: "In the past, doctors needed to collect samples and then send frozen sections to pathologists. Then everyone waited for the pathologist's medical report to determine if they had been completely removed. Cancer organization."

Lichtenfeld added: "In addition, if the cancer lesions cannot be completely removed during surgery, it will bring more complicated complications to the patient. And the real problem is that if you can't clear all the cancer tissues, you will leave hidden dangers. Leave a shelter for tumor cells to survive, develop, and even spread to other parts of the body."

Although this cancer detection pen is very fast, it does not mean that it is not accurate. The researchers said that after analyzing the samples of 300 patients, they found that the technology can diagnose four types of cancer with more than 96% accuracy, namely breast cancer, thyroid cancer, ovarian cancer and lung cancer. Technology also eliminates the risk of normal tissue being removed. "

Sans said: "This technology will bring huge benefits to patients and the health care system." Lichtenfeld is also very optimistic about this technology, he said: "We must understand a concept from confirming that it is effective to the real application of medicine. It takes a long time. We still can't understand the future fate of this technology, but the researchers know that they still have a lot of work to do."

The MasSpec probe has not been tested on human patients during surgery. In the coming months, three probes will be installed in hospitals in Texas, including the Dell Medical School, the Anderson Cancer Research Center, and Baylor College of Medicine. The US Food and Drug Administration has approved the technology, but it still takes years of regulation.

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